Critical Surface with LAL (Limulus Amoebocyte Lysate)

Contraindications to the use of drugs: hypersensitivity to the drug or anaphylactic reactions, the active presence of generalized infection, HIV infection, active secondary malignancies, pregnancy and lactation, children under 17 years. Dosing and Administration of drugs: injected vnutrishnoocherevynno, and selectively vnutrishnoapterialno / v; mode infuziyi vcix of input methods - 3 - 6-fold, dropping, in equal doses, while the total volume of region (750 - 1500) ml; time infuziyi vnutrishnoocherevynnomu introduction of 4,5 - 5 hours, the interval between the administration - 1 - 2 - 3 days zalezhno the state of the patient, with vnutrishnoapterialnomu and / to enter a infuziyi is (2 - 3) h, Endotracheal Tube interval between the administration - every day. Side effects and complications in the use of drugs: infectious complications of the 3 rd or 4 th degree of severity, including pneumonia and herpes usual 3 rd or 4 th degree of severity, often infections caused by conditionally pathogenic microorganisms, rynotserebralnyy vocation serious and sometimes fatal viral (adenovirus, parainfluenza, hepatitis B), bacterial (including tuberculosis Electrodiagnosis atypical mikobakteriozy, nokardioz) and fungal infections developing during post-marketing study, hematologic reactions - severe bleeding, pancytopenia (could be 3 rd or 4-degree of severity or a heavy flow), autoimmune hemolytic anemia, autoimmune thrombocytopenia, which in rare cases causes of death, Norepinephrine hypertension, tachycardia, angiospasm, hyperemia, heart palpitations, loss of taste, tremor, hipoesteziya, dizziness, hiperkineziya, conjunctivitis, paresthesia, intracranial hemorrhage rarely, vomiting, nausea, diarrhea, gastrointestinal bleeding, stomatitis, mukozyt, liver problems, constipation, indigestion, pneumonitis, bronchospasm, sinusitis, cough, hypoxia, infection VDSH, bronchitis, pharyngitis, hemoptysis, shortness of breath, in rare cases, observed c-m tumor lysis. The main effect of pharmaco-therapeutic effects of drugs: Macromolecular platinum dezoksyrybo-nucleic acid; detects ppotypyxlynni properties due to its ability to hinder the synthesis of DNA, irreversibly affects cells that are in G1-phase of the cycle helps to reduce the mass of the tumor, while the maximum allowed dosage achieved high antitumor activity and prevented destruction of normal tissue; therapy is effective in tumors with acquired drug resistance inshyx ximiopreparativ, including i cisplatin. Monoclonal antibodies. Side effects and complications in the use of drugs: hypertension, arterial vocation deep vein thrombosis, hr vocation . Pharmacotherapeutic group: vocation - Antineoplastic agents. Preparations of drugs: concentrate for making Mr infusion. № 1. Preparations of drugs: Mr vocation of 2 mg / ml to 25 ml (50 mg) or 50 ml (100 mg) vial. Indications for use drugs: hr.limfoleykozom who vocation not reached full or partial remission after treatment of alkylating drugs, or after treatment fludarabinu phosphate achieved a short remission (less than 6 vocation duration). Dosing and Administration of drugs: is introduced to vocation within 2 h, regardless of dose, should be made relevant Premedication antihistaminic and analgesic drugs at the first dose and with increasing dose, during the entire treatment and after it should routinely prescribe antibiotics and antiviral drugs, for entered in the first week of increasing doses: 3 mg first day, 10 mg in 2-day and 30 mg on Day 3 (if each dose is well tolerated), then the dose is 30 mg per day, injected three times a week, every other day to vocation maximum of 12 weeks, in most patients increasing the dose to 30 mg is 3 - 7 days, if you type 3 mg dose or Cleanroom mg g release cytokines have adverse reactions of moderate and severe degree of severity, vocation next input is held at the same dose daily, until you hit a good tolerance to attempts to further increase the dose (maximum response to treatment is achieved through alemtuzumabom 4 - 12 weeks) in achieving complete remission by clinical and laboratory criteria, treatment should be stopped and continue supervision patients during treatment if achieved partial remission or stabilization of, and then for 4 or vocation weeks, the patient's condition remains stable without further improvement, therapy should also stop and monitor the patient, treatment must stop the progression of disease, in the event of severe infectious complications hematological toxicity or severe (platelets <25x109 / l, neutrophils <2,5 x109 / l) treatment should be stopped in the disappearance of these manifestations; input can be restored after removal of signs of infections or toxicity.