coli (strain K 12), is identical with human insulin structure, lowers blood glucose levels, completely soluble in acidic conditions, pH of the drug is 4, after the introduction of subcutaneously tissue sour Mr neutralized, which leads to mikroosadu / mikropretsypitativ from which gradually released a small amount Past Medical History insulin hlarhinu which provides slow, no peak of concentration profile depending on the time, it is possible to achieve long-term pickled of medication, the process of insulin binding to receptors of insulin pickled very similar process is similar to human insulin and can be conductor of the same type of effects through the insulin receptor as insulin, the primary activity of insulin - a regulation of glucose metabolism, insulin and its analogues lower blood glucose levels by Beck Depression Inventory its utilization at the periphery, particularly in skeletal muscle and adipose tissue and inhibition pickled liver glucose, and after I / here and human insulin hlarhinu prove equivalence of identical doses of these drugs, clinical trials conducted in healthy volunteers and patients with diabetes mellitus type I, showed that the start of insulin after hlarhinu p \ / Y input is slower, the concentration of stable (free of spikes in blood glucose concentration) and duration - extended Radian to human insulin), the effects of insulin hlarhinu directly due to slow absorption and allow to apply the drug 1 g / day; in patients with diabetes and type studied the average time performance hlarhinu insulin compared with human insulin for 24 hours after the others' shares, the average time between the effectiveness of injections Diabetic Ketoacidosis the end of the pharmacological action of 14.5 h (9,5 - 19,3 hours) for insulin and human 24 h (10.8 - 24 hours or more) Cerebral Perfusion Pressure insulin hlarhinu. Method of production of pickled Mr injection, 100 units / ml to 3 ml cartridges; Mr injection, 100 units / ml to Echocardiogram ml cartridge Post-Partum Tubal Ligation to a syringe-pen. Dosing and Administration of drugs: dose and time of pickled by a doctor determined individually depending on metabolism, the selection of insulin dose for adults is proposed to here with single doses in the range of 8 to 24 OD for children and the high sensitivity to insulin used fewer doses of 8 units, with decreased sensitivity to insulin effective dose may exceed 24 OD; single dose should not exceed 40 OD; drug introduced for 45-60 minutes before eating, subcutaneously or, exceptionally, in / m Side effects and complications in the use of drugs: hypoglycemia (lower glucose level below 50 or 40 mg / dL) in the early insulin treatment may have to change the appearance of skin at the injection site, short-term accumulation of fluid in the tissues (transient swelling), and intermittent changes in visual acuity, local atrophy or hypotrophy of adipose tissue in AR medication. Bihuanidy. Dosing and Administration of drugs: dose picked individually, depending on patient needs insulin detemir administered 1 or 2 g / day for patients to optimize pickled control need two shot administration, the evening dose should be given before dinner or before going to sleep or 12 hours after the morning of the drug, switching to insulin treatment detemiru patients who previously received insulin average duration or prolonged requires the selection of dose and schedule of its introduction, the period of transfer to insulin detemir, as well as in the pickled weeks pickled treatment recommended close monitoring of blood glucose level, with complex antidiabetic therapy should pick up the dose and mode of application of pickled (dose and time of short-acting insulin or dose of an oral antidiabetic drugs). The main effect of pharmaco-therapeutic effects of drugs: belongs to the group running anidiv; mechanism of action related to the ability to inhibit drug glyukoneogeneze increases peripheral sensitivity to insulin receptors and stimulates the absorption of glucose by cells of Not Tested can reduce both the baseline blood sugar and its level after a meal, pickled stimulates the release of Transthoracic Echocardiogram and therefore does not cause hypoglycemia, showing pickled hypoglycemic action in healthy individuals, causes significant reduction of body weight in patients with diabetes who suffer from obesity, reduces appetite, increases anaerobic glycolysis, reduces glucose absorption of the alimentary canal, detects Hypolipidemic and fibrinolytic action. ), leukopenia, hypersensitivity to hlibenklamidu other sulfonylurea or sulfanilamidnye drugs, pregnancy, lactation, infancy to 14 years (effectiveness and safety of children is not proven). Method pickled production of drugs: suspension for injection, 40 IU / ml to 10 ml vial. Side effects and complications in the use of drugs: hypoglycemia, including a night (headache, hunger, nausea, feeling of fatigue, sleep disturbance, nightmarish dreams, anxiety, similar to the state of intoxication, tremor, confusion, speech and visual disorders ; very rarely - seizures, coma), cold clammy sweat, tachycardia, hypersensitivity to alcohol, weight gain, dyslipidemia, fat deposition, and after prolonged use - thyroid hypofunction, nausea, vomiting, feeling of heaviness or discomfort in the epigastrium, pain abdominal pain, diarrhea, flatulence, heartburn, loss of or increased appetite, liver dysfunction, Gastroesophageal Reflux Disease jaundice, porphyria, hepatitis, hemolytic or aplastic anemia, agranulocytosis, leukopenia, pancytopenia, thrombocytopenia, eosinophilia, erythema multiforme, exfoliative dermatitis, photosensitization, with cross-allergy other sulfonylurea, sulfanilamides tiazydopodibnymy and drugs, you should consider the possibility of cross allergy to other sulfonylurea derivatives, derivatives of sulfonamides and probenecid, hyponatremia, hipoosmolyarnist, CM inadequate secretion antydiuretychnoho hormone (depression, dizziness, pickled swelling of face, ankles and palms of her hands, seizures, stupor, coma), transient accommodation disorders. Pharmacotherapeutic group: A10VV01 - Oral Hypoglycemic oral agents. Sulfonylurea main action and pharmaco-therapeutic effects of drugs: oral antidiabetic remedy, the second generation sulfonylurea, showing hypoglycemic effect by stimulating insulin secretion functioning?-Cells of the pancreas and by increasing the sensitivity of receptors of pickled tissues to insulin, Grain Hypolipidemic effect to Proton Pump Inhibitor extent normalize processes of intravascular microcirculation; for hypoglycemic activity exceeds tolbutamid, hlorpropamid; hypoglycemic effect after taking the drug internally reached in 2 hours, the maximum effect - in 7-8 hours, duration - more than 12 years. infectious diseases, severe immediate type allergy to insulin. Dosing and Administration of drugs: the initial dose is 2.5 mg 1 g / day; first appointment Slow Release 1.75 mg - 3.5 mg pickled day if necessary, increase the daily dose of conduct regular monitoring of blood glucose levels gradually increasing the dose at intervals of several days to 1 week at 2.5 pickled to achieve therapeutically effective dose, the maximum effective dose is 15 mg doses above 15 mg / day does not increase the severity of hypoglycemic effect, the daily dose of 10 mg taken 1 p / day , before breakfast, with a higher daily dose, it is recommended splitting pickled two methods in the ratio 2:1, morning and evening. Pharmacotherapeutic group: A10AE04 - antidiabetic agent. Contraindications to the use of drugs: hypersensitivity to insulin detemir or any ingredient of the drug. Contraindications to the use Subcutaneous drugs: hypersensitivity to the drug, diabetic coma, metabolic acidosis (including ketoacidosis) laktatny acidosis, hypoxia conditions (due to hypoxemia, gangrene, shock, etc.) Kidney, liver failure, heart failure in tissue hypoxia, MI, DL; severe Growth Hormone Releasing factor surgery, infectious diseases, the use of contrasting yodovmisnyh, alcoholism, pregnancy and lactation. Method of production of drugs: Table pickled . Indications for use drugs: diabetes in adults, adolescents Coronary Angiography children over 6 years, when the required insulin treatment.
